张玮莹个人简历
一、个人基本信息
张玮莹，女，汉族，中共党员；博士，副教授，硕士生导师。主持及参与国家重大基金培育计划、国家自然科学基金面上/青年项目、国家自然科学基金面上/青年项目、武汉市应用与基础研究项目等纵向课题20余项，发表SCI论文40余篇，获得国家发明授权专利5项。主要从事纳米生物材料、纳米生物传感、生物医学诊断与治疗等方面研究，取得了一系列创新性成果。
1999.7 至今：江汉大学生命科学学院，工作
二、主要学习及工作经历
（1）2001.9-2005.6：华中师范大学生命科学学院，学士
（2）2007.9-2010.6：华中师范大学生命科学学院，硕士
（3）2010.9-2014.6：华中师范大学生命科学学院，博士
（4）2011.10-2013.10：Pacific Northwest National Laboratory, PNNL (USA)，博士生联合培养
（5）2014.7 至今：江汉大学，工作
（6）2015.7-2015.10：Kyoto University（日本），访问学者
三、主讲课程
本科生课程：《细胞与组织培养实验》、《生物化学》、《细胞工程》、《园艺植物组织培养》
硕士研究生课程：《高级生物化学》
四、荣誉及获奖
指导本科生获得全国大学生生命科学竞赛一等奖，指导多名硕士生获得国家奖学金，被授予“优秀硕士研究生指导教师”荣誉称号。
五、科学研究
1. 主要研究方向
（1）纳米生物材料
（2）纳米生物传感
（3）生物医学诊断与治疗
2. 主要科研项目
（1）国家自然科学基金重大研究计划培育项目“利用微流控芯片技术研究AcSDKP对血管损伤后的重塑作用与机制”（参与），100万，2016-2021，结题.
（2）国家自然科学基金青年项目“一种基于微柱和纳米纤维的3D微流控芯片构建及其在循环肿瘤细胞捕获与释放上的应用研究”（主持），项目编号31600801，20万，2017-2019，结题.
（3）湖北省自然科学基金青年项目“循环肿瘤细胞俘获及相关标志物的微流控芯片多通道检测”（主持），项目编号2015CFB610，8万，2015-2016，结题.
（4）武汉市科技局应用基础研究计划项目“基于微流控芯片的肿瘤细胞与肿瘤分子联合诊断新方法研究”（主持），项目编号2015061701011595，15万，2015-2017，结题.
（5）湖北省自然科学基金面上项目“基于黑磷纳米片的兼具双模态成像与载药功能的分子探针对动脉粥样硬化的诊断和治疗”（主持），项目编号2019CFB558，10万，2019-2021，结题.
（6）江汉大学一流学科建设重大专项“新型共价有机骨架材料在藜蒿黄酮类化合物富集与分析中的应用研究”（主持），项目编号2023XKZ019，25万，2023-2025，在研.
3.主要代表性学术论文及教材
（1）Yuqing He, Ziqi Ye, Fei Zhu, Tianxiang Qiu, Xiyan Dai, Yue Xie, Shibiao Zou, Qingjian Dong, Weiying Zhang*, Junkai Ma, Xiaowei Mao*, Enantioselective Labeling of Zebrafish for D-Phenylalanine based on Graphene-Based Nanoplatform, 2023
（2）LUO Zhang, GONG Chaihong, MAO Xiaowei, WANG Zhe, LiU Zhifan, BEN Yali, ZHANG Weiying*, Integrated Organ-on-a-chip with Human-induced Pluripotent Stem Cells Directional Differentiation for 3D Skin Model Generation. Journal of Wuhan University of Technology-Mater:Sci.Ed. 2022
（3）Chaihong Gong , Xiaowei Mao, Zhe Wang, Zhang Luo, Zhifan Liu, Yali Ben, Weiying Zhang*, Zhenzhong Guo, Near-Infrared Light Regulation of Capture and Release of ctDNA Platforms Based on the DNA Assembly System. Frontiers in Bioengineering and Biotechnology 2022, 10
（4）Yang Lei, Haixia Ye, Siqi Xiang, Yuan Huang, Chao Zhu, Weiying Zhang,* Yong Chen, Yiping Cao*, Pipette-like action of a reusable and NIR lightresponsive film for the aspiration and removal of viable cancer cells. New J. Chem. 2020, 44
（5）Xuanying Li#, Mengsha Ye#, Weiying Zhang#, Duo Tan, Nicole Jaffrezic-Renault, Xu Yang, Zhenzhong Guo, Liquid biopsy of circulating tumor DNA and biosensor applications, Biosensors and Bioelectronics, 2019, 126, 596-607.
（6）J. Liu, W. Chang, L. Pan, X. Liu, L. Su, W. Zhang, Q. Li, Y. Zheng, An Improved Method of Preparing High Efficiency Transformation Escherichia coli with Both Plasmids and Larger DNA Fragments, India Journal of Microbiology, 2018, 58, 448-456.
（7）X. Wu, T. Xiao, Z. Luo, R. He, Y. Cao*, Z. Guo*, W. Zhang*, Y. Chen, A micro-/nano-chip and quantum dots-based 3D cytosensor for quantitative analysis of circulating tumor cells, J. Nanobiotechnol., 2018, 16, 65-73.
（8）H. Liu, M. Ruan, J. Xiao, Z. Zhang, C. Chen, W. Zhang, Y. Cao, R. He*, Y. Liu*, Y. Chen*, TiO2 nanorod arrays with mesoscopic micro-nano interfaces for in situ regulation of cell morphology and nucleus deformation, ACS Appl. Mater. Interfaces, 2018, 10, 66-74.
（9）C. Cai, Z. Guo, Y. Cao*, W. Zhang*, Y. Chen, A dual biomarker detection platform for quantitating circulating tumor DNA (ctDNA), Nanotheranostics, 2018, 2,12-20.
（10）Z. Zheng, H. Ye, J. Wang, T. Zhang, Q. You, H. Li, R. He, Y. Chen, W. Zhang*, Y. Cao*, Visible-light-controllable drug release from multilayer-coated microneedles, J. Mater. Chem. B, 2017, 5, 7014-7017.
（11）W. Zhang*, Z. Guo*, Y. Chen, Y. Cao*, Nanomaterial based biosensors for detection of biomarkers of exposure to OP pesticides and nerve agents: a review, Electroanal, 2017, 29, 1206-1213.
（12）H. Ye, Z. Guo, M. Peng, C. Cai, Y. Chen, Y. Cao*, W. Zhang*, Methyl parathion degrading enzyme-based nano-hybrid biosensor for enhanced methyl parathion recognition, Electroanal., 2016, 28, 1591-1596.
（13）Z. Guo*, A. Florea, M. Jiang, W. Zhang, A. Zhang, R. Sandulescu, N. Jaffrezic-Renault*, Molecularly imprinted polymer/metal organic framework based chemical sensors, Coatings, 2016, 6, 42.
（14）X. Cai, Y. Luo, W. Zhang, D. Du*, Y. Lin*, pH-sensitive ZnO Quantum Dots-doxorubicin nanoparticles for lung cancer targeted drug delivery, ACS Appl. Interfaces, 2016, 8, 22442-22450.
（15）R. He, J. Xiao, M. Zhang, Z. Zhang, W. Zhang, Y. Cao, Y. Liu*, Y. Chen*, Artificial honeycomb-inspired TiO2 nanorod arrays with tunable nano/micro interfaces for improving poly(dimethylsiloxane) surface hydrophobicity, J. Mater. Sci., 2016, 51, 2935-2941.
（16）N. Li, T. Xiao, Z. Zhang, R. He, D. Wen, Y. Cao*, W. Zhang*, Y. Chen, A 3D graphene microchips and an Au-enwrapped silica nanocomposites based supersandwich cytosensor toward capture and analysis of circulating tumor cells, Nanoscale, 2015, 7, 16354- 16360.
（17）J. Wang, J. Li, N. Li, X. Guo, L. He, X. Cao, W. Zhang, R. He*, Z. Qian*, Y. Cao*, Y. Chen, A bottom-up approach to dual shape-memory effects, Chem. Mater., 2015, 27, 2439- 2448.
（18）J. Xiao, W. He, Z. Zhang, W. Zhang, Y. Cao, R. He*, Y. Chen*, PDMS micropillar-based microchip for efficient cancer cell capture, RSC Adv., 2015, 5, 52161- 52166.
（19）W. He, J. Xiao, Z. Zhang, W. Zhang, Y. Cao, R. He*, Y. Chen*, One step electroplating 3D template with gradient height to enhance micromixing in microfluidic chips, Microfluid Nanofluid, 2015, 54, 829-836.
（20）W. Zhang, A.M. Asiri, D. Liu, D. Du, Y. Lin*, Nanomaterials-based biosensors for environmental and biological monitoring of organophosphorus pesticides and nerve agents, Trend Anal. Chem., 2014, 54, 1-10.
（21）W. Zhang, D. Du, D. Gunaratne, R. Colby, Y. Lin*, J. Laskin*, Polyoxometalate-graphene nanocomposites modified electrode for electrocatalytic detection of ascorbic acid, Electroanal., 2014, 26, 178-183.
（22）D. Gunaratne, W. Zhang, Y. Lin, J. Laskin*, Controlling the Charge State and Redox Properties of Supported Polyoxometalates via Soft Landing of Mass-Selected Ions, J. Phys. Chem. C, 2014, 118, 27611- 27622.
（23）X. Ge, W. Zhang#, Y. Lin, D. Du*, Magnetic Fe3O4@TiO2 nanoparticles- based test strip immunosensing device for rapid detection of phosphorylated butyrylcholinesterase, Biosens. Bioelectron., 2013, 50, 486-491.
（24）W. Zhang, Y. Tang, D. Du, J. Smith, C. Timchalk, D. Liu*, Y. Lin*, Direct analysis of trichloropyridinol in human saliva using an Au nanoparticles-based immunochromatographic test strip for biomonitoring of exposure to chlorpyrifos, Talanta, 2013, 114, 261-267.
（25）W. Zhang, X. Ge, Y. Tang, D. Du, D. Liu*, Y. Lin*, Nanoparticle-based immunochromato-graphic test strip with fluorescent detector for quantification of phosphorylated acetylcholinesterase: an exposure biomarker of organophosphorus agents, Analyst, 2013, 138, 5431-5436.
（26）Y. Zhao, W. Zhang, Y. Lin, D. Du*, The vital function of Fe3O4@Au nanocomposites for hydrolase biosensor design and its application in detection of methyl parathion, Nanoscale, 2013, 5, 1121-1126.
（27）L. Zhang, L. Long, W. Zhang, D. Du, Y. Lin*, Study of inhibition, reactivation and aging processes of pesticides using graphene nanosheets/gold nanoparticles-based acetylcholinesterase biosensor, Electroanal., 2012, 24, 1745 – 1750.
（28）D. Du, Y. Tao, W. Zhang, D. Liu*, H. Li, Oxidative desorption of thiocholine assembled on core–shell Fe3O4/AuNPs magnetic nanocomposites for highly sensitive determination of acetylcholinesterase activity: An exposure biomarker of organophosphates, Biosens. Bioelectron., 2011, 26, 4231-4235.
（29）W. Zhang, J. Ding, Y. Qin, D. Liu*, D. Du*, One-step electrochemically deposited gold nanoparticles interface grafted with avidin for acetylcholinesterase biosensor design, J. Nanosci. Nanotech., 2010, 10, 5685-5691.
（30）D. Du*, W. Chen, W. Zhang, D. Liu, H. Li, Y. Lin*, Covalent coupling of organophosphorus hydrolase loaded quantum dots to carbon nanotube/Au nanocomposite for enhanced detection of methyl parathion, Biosens. Bioelectron., 2010, 25, 1370-1375.
4. 授权专利
（1）循环肿瘤细胞检测探针及制备方法及应用诊断传感器（授权号ZL 201510318789.x）, 国家发明专利, 2019, 排序第一.
（2）一种循环肿瘤DNA检测方法，探针及传感器（授权号ZL 20171058484.4）, 国家发明专利, 2021, 排序第一.
（3）基于器官芯片与诱导多能干细胞的定向分化用于3D拟表皮构建的方法（授权号ZL 201711373861.4）, 国家发明专利, 2022, 排序第一.
序第一22cle-based immunochromato- （4）一种酶交联水凝胶的制备方法及其应用（授权号ZL 201710822630.0）, 国家发明专利, 2021, 排序第四.
（5）一种不同高度微纳米柱衬底制备装置（授权号ZL 201620472731.0）, 实用新型专利, 2018, 排序第五.