刘小云

发布者：吕方舟发布时间：2024-09-13浏览次数：75

刘小云个人简历

一、个人基本信息

刘小云，女，汉族，中共党员；博士，副教授，硕士生导师。主持及参与10余项国家及湖北省自科基金等纵向课题，在国内外发表学术论文30余篇，获得国家授权专利5项以及软件著作权登记2项。主要从事表观修饰在植物（作物）发育与逆境响应中的调控机制研究；表观遗传调控相关技术的研发；生物信息和表观修饰在农业生产以及药物开发中的应用。


二、主要学习及工作经历

（1）2001.09-2005.07：华中师范大学生命科学学院，本科

（2）2006.09-2008.12：华中农业大学植物科学与技术学院，硕士

（3）2010.09-2014.12：华中农业大学生命科学技术学院，博士

（4）2015.01-2015.05：华中农业大学，研究助理

（5）2015.06至今：江汉大学生命科学学院，工作

（6）2019.08-2020.09：Michigan State University （美国），访问学者


三、主讲课程

本科生课程：《分子生物学》、《花卉保鲜学》、《农产品贮藏保鲜学》、《专业英语》等；

硕士研究生课程：《分子生物学》、《基因组学》、《植物营养学》


四、荣誉及获奖

2018年武汉市博士资助奖励；多次指导本科生获得全国大学生生命科学竞赛国家及湖北省赛区奖项。


五、科学研究

1. 主要研究方向

（1）植物发育与逆境表观调控

（2）表观修饰相关技术开发

（3）表观修饰因子相关的应用开发


2. 主要科研项目

（1）国家自然科学基金青年基金项目，31600981，组蛋白H3K27me3修饰对水稻花粉发育的调控机理研究，2017.01-2019.12（主持）

（2）湖北省自然科学基金面上项目，2023AFB982, 新型“植物源小分子”去乙酰化酶抑制剂对植物病原菌的抑制机制，2023.07.01-2025.06.30（主持）

（3）江汉大学高层次人才启动经费，水稻花粉发育的表观调控机理研究（1019-06210002），2017.01-2019.12（主持）

（4）武当特色中药研究湖北省重点实验室开放课题，WDCM2020008,基于表观遗传学研究温度对珠子参道地性的影响，2021.06-2022.06（主持）

（5）武当特色中药研究湖北省重点实验室开放课题，WDCM2022014, 基于流式细胞仪和和K-mer分析预测珠子参的基因组大小，2022.06-2023.06（主持）

（6）农业农村部油料作物生物学与遗传育种重点实验室2024年开放课题，组蛋白修饰参与甘蓝型油菜响应干旱的调控机制，KF2024008，2024.7-2025.12，（主持）

（7）江汉大学四新学科专项，2022ZX-3-03，柠檬草挥发油对水稻耐砷胁迫的诱抗效应和分子机制研究，2022.11-2024.11，（主持）

（8） 国家自然科学基金面上项目，31371468，水稻冠根发育调节因子WOX11互作蛋白的鉴定及作用机理研究，2014.01-2017.12（参与）

（9）国家自然科学基金面上项目，31571256，水稻幼穗分化过程基因表达重编程的染色质基础研究，2016.01-2019.12（参与）

（10）国家自然科学基金面上项目，22076065，基于DNA甲基转移酶介导的典型三价砷化合物直接与间接调控DNA甲基化的分子机制，2021.01-2024.12（参与）


3.主要代表性学术论文

  (1) Ping Wang#, Lufang Su#, Lan Cao, Hanbing Hu, Heping Wan, Chunhong Wu, Yu Zheng,

Chun Bao, Xiaoyun Liu*, AtSRT1 regulates flowering by regulating flowering integrators and energy signals in Arabidopsis, Plant Physiology and Biochemistry, 2024, 213-108841.

  1. Zhou Hanlin, Yuan Zhu, Han Sifang, He Huan, Rong Jiajia, Guo Dandan, Zhang Yonghong,

Zhang Dechun, Liu Xiaoyun*, Zhou Chao*. Global Decrease in H3K9 Acetylation in Sorghum Seed Postgermination Stages. Journal of Agriculture and Food Chemistry. 2023, 71(14):5836-5850.

  1. Lufang Su # , Dandan Guo # , Heping Wan , Ping Wang, Lan Cao , Yanmin Long , Chaohui

Chen , Yangyang Song , Yonghong Zhang , Changli Zeng*, Rui Guo*, Xiaoyun Liu*. Transcriptomic and metabolomic insights into the defense response to HFRs in Arabidopsis. Ecotoxicology and Environmental Safety. 2023; 254:114736.

  1. Hanlin Zhou #, Ruizhi Yan # , Huan He # , Xinlin Wei , Shuangcheng Liu , Bintao Guo ,

Yonghong Zhang , Xiaoyun Liu, Shafeeq Ur Rahman , Chao Zhou*, Zhengquan He*. Transcriptional profiling of long noncoding RNAs associated with flower color formation in Ipomoea nil. Planta. 2023, 258(1):6.

  1. Yu Zheng, Zhenting Li, Xiaoyun Cui , Zheng Yang, Chun Bao, Lei Pan, Xiaoyun Liu, Gilles

Chatel-Innocenti, Hélène Vanacker, Graham Noctor, Avilien Dard, Jean-Philippe Reichheld, Emmanuelle Issakidis-Bourguet, Dao-Xiu Zhou. S-Nitrosylation of the histone deacetylase HDA19 stimulates its activity to enhance plant stress tolerance in Arabidopsis. The Plant Journal. 2023, 114(4):836-854.

  1. Zhou Hanlin#, Liu Xiaoyun#, Zhou Chao, Han Sifang, Xu Furong, Dong Xian.

Root-Associated Microbiomes of Panax notoginseng under the Combined Effect of Plant Development and Alpinia officinarum Hance Essential Oil. Molecules. 2022;27(18):6014.

  1. Liu Xiaoyun, Huo Yingying, Yang Jing, Li Tiantian, Xu Furong, Wan Heping, Li Jianan, Wu

Chunhong, Zhang Yonghong, Dong Xian. Integrated physiological, metabolomic, and proteome analysis of Alpinia officinarum Hance essential oil inhibits the growth of Fusarium oxysporum of Panax notoginseng. Frontiers In Microbiology. 2022 ,13:1031474.

  1. Zhou Chao # , Liu Xiaoyun # , Li Xinglei #, Zhou Hanlin, Wang Sijia, Yuan Zhu, Zhang

Yonghong, Li Sanhe, You Aiqing, Zhou Lei*, He Zhengquan*. A Genome Doubling Event Reshapes Rice Morphology and Products by Modulating Chromatin Signatures and Gene Expression Profiling. Rice. 2021, 14(1):72.

  1. Zheng Lanlan#, Li Chen#, Ma Xueping, Zhou Hanlin, Liu Yuan, Wang Ping, Yang Huilai,

Tamada Yosuke, Huang Ji, Wang Chunfei, Hu Zhubing, Wang Xuening, Wang Guodong, Li Haihong, Hu Juntao, Liu Xiaoyun*, Zhou Chao*, Zhang Yonghong*. Functional interplay of histone lysine 2-hydroxyisobutyrylation and acetylation in Arabidopsis under dark-induced starvation. Nucleic Acids Res. 2021,49(13):7347-7360.

  1. Xiaoyun Liu*#, Junling Luo #, Tiantian Li, Huilan Yang, Ping Wang, Lufang Su, YuZheng,

Chun Bao, Chao Zhou*. SDG711 is involved in rice seed development through regulation of starch metabolism gene expression in coordination with other histone modifications. Rice, 2021, 14(1):25.

  1. Chao Zhou, Hanlin Zhou, Xueping Ma, Huilan Yang, Ping Wang, Guodong Wang, Lanlan

Zheng, Yonghong Zhang* and Xiaoyun Liu*. Genome-Wide Identification and Characterization of Main Histone Modifications in Sorghum Decipher Regulatory Mechanisms Involved by mRNA and Long Noncoding RNA Genes. Journal of Agriculture and Food Chemistry, 2021, 69(7):2337-2347.

  1. Chen, chaohui*; Song, Qingyuan; Lu, Wangting; Zhang, Zhengtao; Yu, Yanhua; Liu, Xiaoyun; He, Rongxiang*. A sensitive platform for DNA detection based on organic electrochemical transistor and nucleic acid self-assembly signal amplification. RSC Advances, 2021, 11(60):37917-37922.

  2. Chao Zhou*, Zhu Yuan, Xueping Ma, Huilan Yang, Ping Wang, Lanlan Zheng, Yonghong

Zhang* and Xiaoyun Liu*. Accessible chromatin regions and their functional interrelations with gene transcription and epigenetic modifications in sorghum genome. Plant Communications, 2020, 2(1):100140.

  1. Chongwei Tu, Tiantian Li, and Xiaoyun Liu*. Genetic and epigenetic regulatory mechanism

of rice panicle development. 2018 INTERNATIONAL CONFERENCE ON BIOTECHNOLOGY AND BIOENGINEERING (8TH ICBB), AIP Conference Proceedings 2079, 020001 (2019).

  1. Yu Zheng#*, Jingyu Ge#, Chun Bao, Wenwen Chang, Jingjing Liu, Jingjie Shao, Xiaoyun

Liu, Lufang Su, Lei Pan, Dao-Xiu Zhou*. Histone deacetylase HDA9 and transcription factor WRKY53 are mutual antagonists in regulation of plant stress response. Molecular Plant, 2019, 13(4): 598-611

  1. Yuan Shen#，Tingting Lei#，Xiaoyun Cui，Xiaoyun Liu，Shaoli Zhou，Yu Zheng

Florence Guérard，Emmanuelle Issakidis‐Bourguet ，Dao‐Xiu Zhou*. Arabidopsis histone deacetylase HDA 15 directly represses plant response to elevated ambient temperature. The Plant Journal，2019，100(5): 991-1006

  1. Jingjing Liu, Wenwen Chang, Lei Pan, Xiaoyun Liu, Lufang Su, Weiying Zhang, Qin Li &

Yu Zheng. An Improved Method of Preparing High Efficiency Transformation Escherichia coli with Both Plasmids and Larger DNA Fragments. Indian Journal of Microbiology. 2018，58(4):448-456.

  1. Saifeng Cheng, Feng Tan, Yue Lu, Xiaoyun Liu, Tiantian Li, Wenjia Yuan, Yu Zhao,

Dao-Xiu Zhou *.WOX11 recruits a histone H3K27me3 demethylase to promote gene expression during shoot development in rice. Nucleic Acids Res. 2018, 46(5):2356-2369.

  1. Xiaoyun Liu#, Wei Wei#, Wenjun Zhu, Lufang Su, Zeyang Xiong, Man Zhou, Yu Zheng ,

Dao-Xiu Zhou *. Histone Deacetylase AtSRT1 Links Metabolic Flux and Stress Response in Arabidopsis. Molecular Plant, 2017, 10(12): 1510-1522.

  1. Shaoli Zhou#, Xiaoyun Liu#, Chao Zhou#, Qiangwei Zhou, Yu Zhao, Guoliang Li, Dao-Xiu

Zhou*, Cooperation between the H3K27me3 chromatin marker and non-CG methylation in epigenetic regulation. Plant Physiol, 2016, 172 (2) :1131-1141

  1. Yu Zheng*, Yue Ding, Xuan Sun, Sisi Xie, Dan Wang, Xiaoyun Liu, Lufang Su, Wei  

Wei, Lei Pan and Dao-Xiu Zhou*, Histone deacetylase HDA9 negatively regulates salt and drought stress responsiveness in Arabidopsis, Journal of Experimental Botany, 2016，67 (6): 1703-1713

  1. Xiaoyun Liu#, Shaoli Zhou#, Wentao Wang, Yiran Ye, Yu Zhao,Qiutao Xu, Chao Zhou,

Feng Tan, Saifeng Cheng, Dao-Xiu Zhou*, Regulation of Histone Methylation and Reprogramming of Gene Expression in the Rice Inflorescence Meristem, The Plant cell, 2015, 27(5): 1428-1444

  1. Xiangsong Chen, Xiaoyun Liu, Yu Zhao, Dao-Xiu Zhou*, Histone H3K4me3 and

H3K27me3 regulatory genes control stable transmission of an epimutation in rice, Scientific Reports, 2015, 5: 13251

  1. Yu Zhao#*, Saifeng Cheng#,Yaling Song,Yulan Huang, Shaoli Zhou, Xiaoyun Liu, Dao-Xiu Zhou*, The Interaction between Rice ERF3 and WOX11 Promotes Crown Root Development by Regulating Gene Expression Involved in Cytokinin Signaling, The Plant Cell, 2015, 27(9): 2469–2483

  2. Ning Zhu, Saifeng Cheng, Xiaoyun Liu, Hao Du, Mingqiu Dai, Dao-Xiu Zhou, Wenjing Yang, Yu Zhao*, The R2R3-type MYB gene OsMYB91 has a function in coordinating plant growth and salt stress tolerance in rice, Plant Science, 2015, 236:146-156

  3. Xiaoyun Liu, Chao Zhou, Yu Zhao, Shaoli Zhou, Wentao Wang, Dao-Xiu Zhou*, The Rice

Enhancer of Zeste [E (z)] Genes SDG711 and SDG718 are respectively involved in Long

Day and Short Day Signaling to Mediate the Accurate Photoperiod Control of Flowering time, Frontiers in Plant Science, 2014, 5:591

  1. Tiantian Li, Xiangsong Chen, Xiaochao Zhong, Yu Zhao, Xiaoyun Liu, Shaoli Zhou,

Saifeng Cheng, Dao-Xiu Zhou*, Jumonji C Domain Protein JMJ705-Mediated Removal of Histone H3 Lysine 27 Trimethylation Is Involved in Defense-Related Gene Activation in Rice, The Plant cell, 2013, 25(11): 4725–4736

  1. 苏鲁方,王萍,李顺，蔡燕, 郭丹丹, 刘琴, 刘小云*.植物sirtuin蛋白家族研究进展[J].植物学报，2023,58(06):998-1007.

  2. 苏鲁方,刘小云,郑瑜,包纯,蒋曹德, 山羊PHLDA2启动子克隆和甲基化分析，自然科学，2022, 10(3):11.

  3. 苏鲁方，李振庭，郑瑜，包纯，刘小云*.基因组印记的研究进展[J].安徽农业科学，2021,49(07):8-11+16.

  4. 刘小云*，李晓，李腾飞，苏鲁方.水稻OsENO2-2基因过表达影响水稻开花期 中国水稻科学，2018, 32（1）：12-22. 中文核心期刊TOP5%

  5. 刘小云*，吴邦庭，邱璐. 植物逆境响应的表观遗传调控研究进展，江汉大学学报(自然科学版)，2018，46（2）：180-187


4. 授权专利和计算机软件著作权登记

（1）一种用于筛选结合和/或激活EGFR的有毒金属的表达蛋白及制备(授权号ZL 202211197889.8), 国家发明专利, 2024, 排序第三.

（2）一种结构肽段的cDNA、结构肽段和制备方法及应用方法(授权号ZL 202211213501.9), 国家发明专利,2024, 排序第三.

（3）影响水稻开花期和粒型的烯醇化酶基因OsENO2-2及其应用(授权号ZL 201710284903.0), 国家发明专利, 2020, 排序第一.

（4）组蛋白甲基转移酶基因在调控水稻开花期和穗型中的应用(授权号ZL 201310079799.3), 国家发明专利,2015, 排序第二.

（5）进水器(授权号ZL 202330244404.5), 外观设计专利, 2023, 排序第二.

（6）FragFinder数据管理系统V1.0，计算机软件著作权登记（登记号：2024SR0283309），2024，排序第二

（7）基于SpringBoot 的芳香植物活性成分挖掘系统V1.0，计算机软件著作权登记（登记号：2024SR1103311），2024，排序第二

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