王卫华个人简历
一、个人基本信息
王卫华,男,汉族;博士,副研究员,入选楚天学者计划。主要从事哺乳动物器官发育和细胞器发生及相关调控机制等方面的研究,相关工作发表在eLife,Hepatology等知名学术期刊上。
二、主要学习及工作经历
(1)2006 — 2010 吉林大学 生命科学学院 学士
(2)2010 — 2013 复旦大学 生命科学学院 硕士
(3)2013 — 2019 北京大学 前沿交叉学科研究院 博士
(4)2019 — 至今 江汉大学 工作
三、主讲课程
本科生课程:《初级卫生保健》;
硕士研究生课程:《医学文献检索》
四、荣誉及获奖
入选楚天学者计划
五、科学研究
主要研究方向
以人类组织细胞和基因编辑小鼠为模式,运用遗传学、生物化学和细胞生物学等研究手段致力于哺乳动物从胚胎发生开始的相关研究:
细胞器发生与动态调控;
器官发育与相关调控机理;
罕见病(线粒体和纤毛相关)重组蛋白药物开发。
主要科研项目
(1)武汉科学技术局, 基础研究, 武科〔2022〕25号, 细胞蛇调节骨吸收的分子机理的研究, 2022-06 至2024-06, 10万元, 结题, 参与
3.主要代表性学术论文及教材
Weihua Wang#*, Junqiao Xing#, Xiqi Zhang#, Hongni Liu, Haochen Jiang, Cheng Xu, Xue Zhao, Zhangfeng Hu*. Control of ciliary transcriptional programs during spermatogenesis by antagonistic transcription factors. eLife, 2024, 13:RP94754
Cheng Xu#*, Zhixin Wei#, Xiaoyu Dong, Junqiao Xing, Xiangrui Meng, Yaxuan Qiu, Huimei Zhou, Wenrui Zheng, Zhenyu Xu, Shanhua Huang, Wenwen Xia, Longfei Lv, Haochen Jiang, Weihua Wang, Xue Zhao, Zixuan Liu, Yoshie Akimoto, Baohong Zhao, Siyuan Wang, Zhangfeng Hu*. A p38 MAP kinase inhibitor suppresses osteoclastogenesis and alleviates ovariectomy-induced bone loss through the inhibition of bone turnover. Biochemical Pharmacology, 2024, 226:116391.
Cheng Xu#*, Zhixin Wei#, Longfei Lv#, Xiaoyu Dong#, Wenwen Xia, Junqiao Xing, Hongni Liu, Xue Zhao, Yuan Liu, Weihua Wang, Haochen Jiang, Yeli Gong, Cong Liu, Kai Xu, Siyuan Wang, Yoshie Akimoto, Zhangfeng Hu*. Impdh2 deficiency suppresses osteoclastogenesis through mitochondrial oxidative phosphorylation and alleviates ovariectomy-induced osteoporosis. Biochemical and Biophysical Research Communications, 2024, 727:150317.
Yang Li#, Li Linchen#, Lamaoqiezhong, Wang Xin, Wang Weihua, Wang Yanchun, Xu Chengran*. The contributions of mesoderm-derived cells in liver development. Seminars in Cell and Developmental Biology, 2018, 92:63-76.
Yang Li#, Wang Weihua#, Qiu Weilin#, Guo Zhen, Bi Erfei, Xu Chengran*. A single-cell transcriptomic analysis reveals precise pathways and regulatory mechanisms underlying hepatoblast differentiation. Hepatology, 2017, 66(5):1387-1401.
Li Jianneng, Wang Wangsheng, Liu Chao, Wang Weihua, Li Wenjiao, Shu Qun, Chen Zijiang, Sun Kang*. Critical role of histone acetylation by p300 in human placental 11 beta-HSD2 expression. J Clin Endocr Metab, 2013, 98(7):E1189-E1197.
Wang Weihua#, Guo Chunming#, Li Wenjiao, Li Jianneng, Wang Wangsheng, Myatt Leslie, Sun Kang*. Involvement of GR and p300 in the induction of H6PD by cortisol in human amnion fibroblasts. Endocrinology, 2012, 153(12):5993-6002.